Rapid Aryne-Mediated Aryl Functionalization via Mechanically Assisted Microscale Mixing

We demonstrate that arynes can be generated and trapped efficiently through mechanically assisted microscale mixing on a standard vortex mixer. Brief vortex agitation enables ultra-fast generation and interception of these highly reactive intermediates with N-, O-, S-, and C-nucleophiles within 1 minute, therefore providing a low-energy-solvent minimized approach for aryl functionalization without the need for inert atmosphere, heating, or bulk solvent.Uploaded files:

1. ZIP-folder: NMR data files for all compounds of this project. These can be opened with all standard NMR-evaluation software (e.g. MestreNova, TopSpin, ACD-Labs, etc.)
2. ZIP-folder: HRMS data files for all newly synthesized compounds of this project. These can be opened with all standard HRMS-evaluation software (e.g. Masshunter)
3. .pdf document with a conversion table of the publication numbers of compounds into the number from the measured files
4. .pdf document with the supporting info for the publication